With the development of research on the impact of immunity and inflammation on cancer,the performance of humanized mice has attracted tremendous attention in clinical oncology research. Generally,humanized mice have been divided into two categories, namely,immunocompromised and immunocompetent mouse models.
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The COVID-19 pandemic caused by the novel coronavirus (SARS-CoV-2) infection has resulted in more than 330 million infections worldwide. The spike (S) protein of SARS-CoV-2 is responsible for host receptor recognition and the fusion of viral and cellular membranes, resulting in viral infection of host cells.
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Bardet-Biedl증후군(BBS)은 희귀한 상염색체 열성유전성(Recessive inheritance) 섬유병으로 Bardet과 Biedl 의사가 각각 이 병의 전형적인 증상을 독자적으로 묘사해 붙여진 이름입니다.BBS 주요 임상표현으로는 망막 영양실조, 선천성 비만, 다지발가락 기형, 생식선 발달 부전, 지적 발달 지연, 신장 이상을 꼽았습니다.
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CAR-T 세포면역요법의 기본원리는 유전공학적(genetic engineering) 수단을 이용하여 T세포 표면에 CAR분자를 표현하는 것입니다. CAR-T세포는 그 표면에 발현된 scFv를 통해 특이하게 종양세포 표면의 항원을 인식해 종양세포를 살상할 수 있습니다.
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The ERCC6 gene is located on human chromosome 10, 10q11, with a total length of 104.7 kb, a total of 23 exons, and 1493 amino acids. Mutations in the ERCC6 gene are closely related to Cockayne syndrome B (CSB).
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This article will focus on HNRNPC mouse model and new research progress. The establishment of these mouse models is helpful for research on the function of the hnRNP C1 and C2 proteins and the regulatory expression of the splicing factor hnRNP C. Insight into new research results is the key for researchers to keep up with hotspots.
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SIRT3 로 인코딩된 단백질은 미토콘드리아에만 존재하며, 여기서 활성산소를 없애고, 세포의 시들어가는 것을 억제하며, 암세포의 형성을 막을 수 있습니다.SIRT3는 핵 유전자 발현, 암, 심혈관질환, 신경보호, 노화와 대사통제에 깊은 영향을 줍니다.
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Mucopolysaccharidosis IVA (MPS IVA) - also known as Morquio Syndrome, type A - is inherited in an autosomal recessive manner and caused by mutations in the GALNS gene which lead to N-acetylgalactosamine-6-sulfate sulfatase (GALNS) deficiency, resulting in the accumulation of keratan sulfate (KS) and chondroitin-6-sulfate (C6S).
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ADAMTS-5 is a metalloproteinase that plays an important role in connective tissue organization, development, inflammation and cell migration. In previous studies, Nakada M et al. have demonstrated that ADAMTS-5 is capable of digesting brevican in an identical pattern to ADAMTS-4, and is overexpressed by glioblastoma cells.
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Humanized mice models carry a short strand of human DNA, cells, or tissues so that in-vivo studies of human systems . Due to this, there is a high demand across preclinical and clinical research for humanized animal models that may improve the safety and efficacy of drug development.
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