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Gene Family Strain Knockout Mice Conditional Knockout Mice Application Description
METTL Family
(Methyltransferase)
Mettl3 Mettl3 KO Mice Mettl3 cKO Mice m6A DNA methylation METTL3 and METTL14 in the METTL family are studied more than others.The m6A modification mediated by METTL3 plays a significant role in biorhythm, DNA damage response (DDR),regulation of stem cell self-renewal and pluripotency, parent-zygote transformation, neuro-regulation and sex determination in drosophila,  various biological processes and ontogenesis development of eukaryotes such as early embryonic development of mice. The knockout of Mettl3 can cause the death of mice embryo, and the in vivo biology function of Mettl3-mediated m6A RNA modification in tissue development is largely unknown in mammals. For germ cell-specific( (Vasa-Cre) Mettl3 knockout mice (Mettl3 cKO) model, the ablation of Mettl3 in germ cells severely inhibited spermatogonial differentiation and blocked the initiation of meiosis in mice, resulting in male infertility.Specific inactivation of Mettl3 in the central nervous system (CNS) can cause severe dyskinesia or even death in mice during lactation.
METTL Family
(Methyltransferase)
Mettl14 Mettl14 KO Mice Mettl14 cKO Mice m6A DNA methylation Germ cell-specific Mettl3 or Mettl14 knockout with Vasa-Cre in mice can bring the loss of m6A, then cause proliferation of spermatogonial stem cells (SSCs) and translation dysfunction of differentiation-associated gene transcript, eventually result in the depletion of spermatogonial stem cells (SSCs). Combined deletion of Mettl3 and Mettl14 will impair the translation of haploid-specific genes  for spermiogenesis, and finally result in spermatogenesis arrest.Specificl inactivation of Mettl14 in central nervous system (CNS)in mice can cause severe impact on its cerebral cortical development.
METTL Family
(Methyltransferase)
Mettl1 Mettl1 KO Mice Mettl1 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl2 Mettl2 KO Mice Mettl2 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl5 Mettl5 KO Mice Mettl5 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl7a1 Mettl17a1 KO Mice Mettl17a1 cKO Mice / The expression of Methyltransferase Mettl7a1 is associated with the successful reprogramming trajectory, and adding Mettl7a1 to the reprogramming cocktail increases the yield of induced endoderm progenitors.
METTL Family
(Methyltransferase)
Mettl7b Mettl7b KO Mice Mettl7b cKO Mice / /
METTL Family
(Methyltransferase)
Mettl6 Mettl6 KO Mice Mettl6 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl8 Mettl8 KO Mice Mettl8 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl10 Mettl10 KO Mice Mettl10 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl11b Mettl11b KO Mice Mettl11b cKO Mice / /
METTL Family
(Methyltransferase)
Mettl9 Mettl9 KO Mice Mettl9 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl13 Mettl13 KO Mice Mettl13 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl15 Mettl15 KO Mice Mettl15 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl16 Mettl16 KO Mice Mettl16 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl17 Mettl17 KO Mice Mettl17 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl20 Mettl20 KO Mice Mettl20 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl21a Mettl21a KO Mice Mettl21a cKO Mice / /
METTL Family
(Methyltransferase)
Mettl21c Mettl21c KO Mice Mettl21c cKO Mice / /
METTL Family
(Methyltransferase)
Mettl21e Mettl21e KO Mice Mettl21e cKO Mice / /
METTL Family
(Methyltransferase)
Mettl22 Mettl22 KO Mice Mettl22 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl23 Mettl23 KO Mice Mettl23 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl24 Mettl24 KO Mice Mettl24 cKO Mice / /
METTL Family
(Methyltransferase)
Mettl25 Mettl25 KO Mice Mettl25 cKO Mice / /
YTHDF Family Ythdf1 Ythdf1 KO Mice Ythdf1 cKO Mice m6A DNA methylation YTHDF Family is the most popular research object in "reader" for it participates in the translation and degradation of protein extranuclear. YTHDF1 protein, mainly binding to the m6A site of mRNA,  it plays an essential role in brain development, dopamine secretion, synaptogenesis, and other processes.
YTHDF Family Ythdf2 None Ythdf2 cKO Mice m6A DNA methylation YTHDF2 is the first protein being identified as the reader of m6A. YTHDF2-mediated degradation of m6A-containing mRNA is also the first aspect that known by humankind in the influence of m6A on the fate of mRNA.
YTHDF Family Ythdf3 Ythdf3 KO Mice Ythdf3 cKO Mice m6A DNA methylation Together with YTHDF1 and YTHDF2, YTDHF3 plays a critic role in speeding up the metabolism of m6A-mediated mRNA in the cytoplasm. All these 3 YTHDF proteins can influence the  m6A RNA DNA  methylation related basic biology process through integration and collaboration.
NLRP Family(67) NLRP1 None None Immunity Nucleotide-binding oligomerization domain-like receptor protein 1(NLRP1) inflammasome is a kind of protein complexes formed by the combination of molecules (such as apoptosis-related specular protein (ASC) and caspase-1 and caspase-5 precursors) and the NLRP1 after identification of intracellular pathogen-associated molecular patterns (PAMP). After activation, it promotes the maturation and release of IL-1β, IL-18, IL-33, and other inflammatory factors, and plays an important role in innate immunity.
NLRP Family(67) NLRP3 None None Immunity NLRP3, as the important component of innate immunity, plays a critic role in the immune response and disease development. Overactivation of NRLP3 can induce various major human diseases, such as Alzheimer's disease (AD), inflammatory bowel disease (IBD) , diabetes and cancer.
NLRP Family(67) NLRP6 NLRP6 KO Mice NLRP6c KO Mice Immunity NLRP6, short for the NOD-like receptor family pyrin domain containing 6, is a protein with a unique function in the NLRs family. NLRP6 is highly expressed in intestine, which can inhibit inflammation and repair damaged intestine. According to research, its deficient expression with inflamed colon and colorectal cancer indicates that NLPR6 could be the potential new targeting treatment of cancer for its function in promoting apoptosis and preventing tumor development.
NLRP Family(67) NLRP10 NLRP10 KO Mice NLRP10c KO Mice Immunity NLRP10 can promotes the NOD1 mediated immune reponse as well as inhibit the activation of NLRP3 inflammasome.
NLRP Family(67) NLRP12 NLRP12 KO Mice NLRP12 cKO Mice Immunity Some research showed that NLPR12 is closely associated with inflammatory bowel disease (IBD), and it may play a dual function in the development of enteritis. Increased colonic inflammation and antimicrobial peptide production in Nlrp12-/- mice may promote dysbacteriosis. After high-fat feeding, Nlrp12 mice display dysbiosis marked by increased obesity-associated Erysipelotrichaceae, but reduced lachnospiraceae and clostridium required for short-chain fatty acid (SCFA) synthesis.
NLRP Family(67) NLRP2 NLRP2 KO Mice NLRP2 cKO Mice Reproduction Nlrp2 is required for early embryonic development in the mouse.
NLRP Family(67) NLRP4 NLRP4a、NLRP4b、NLRP4f KO Mice NLRP4a、NLRP4b、NLRP4e、NLRP4f cKO Mice Reproduction NLRP4 in mice has been duplicated during gene evolution, total of 7 genes from Nlrp4a to Nlrp4g were identified so far. Studies have shown that these 7 Nlrp4 genes have similar expression profiles, which are expressed in oocytes and early embryos in the mouse, while NLRP4 protein does not affect the process of oocyte maturation, but mainly plays a role in early embryonic development.
NLRP Family(67) NLRP5 NLRP5 KO Mice NLRP5 cKO Mice Reproduction NLPR5 plays a vital role in the early embryonic development of mice.
NLRP Family(67) NLRP7 / / Reproduction The human NLRP7 gene is expressed in oocytes and early embryos. Gene mutation cause changes in the encoded protein, and furtherly leading to abnormal development in the earlier human embryonic period.
NLRP Family(67) NLRP8 / / Reproduction /
NLRP Family(67) NLRP9 NLRP9 KO Mice NLRP9 cKO Mice Reproduction NLRP9b model available
NLRP Family(67) NLRP11 / / Reproduction /
NLRP Family(67) NLRP13 / / Reproduction /
NLRP Family(67) NLRP14 NLRP14 KO Mice NLRP14 cKO Mice Reproduction The silencing of the NLRP14 gene from zygotes is known to generate various degrees of developmental arrest during early embryogenesis and cause developmental failure. Besides, the NLRP14 gene also expresses in the sperms of humans and mouse, the mutation of this gene in the human will cause spermatogenic failure. If NLRP14 mutation happens on humans, it will lead to Infertility.
Sirtuins Protein Family(SirtFamily) SIRT1 None None Cell cycle control,  mitochondrial homeostasis maintenance,autophagy and cell growth regulation Majority of SIRT1 KO mice died before and after birth, with retinal, bone and heart defects detected.
Sirtuins Protein Family(SirtFamily) SIRT3 SIRT3 KO Mice SIRT3 cKO Mice Cell cycle control,  mitochondrial homeostasis maintenance,autophagy and cell growth regulation SIRT3KO mice developed normally, the AceCS2 activity, ATP level, and acetylation of mitochondrial proteins changed.
Sirtuins Protein Family(SirtFamily) SIRT4 SIRT4 KO Mice SIRT4 cKO Mice Cell cycle control,  mitochondrial homeostasis maintenance,autophagy and cell growth regulation SIRT4KO mice developed normally, mitochondrial GDH activity increased.
Sirtuins Protein Family(SirtFamily) SIRT5 SIRT5 KO Mice SIRT5 cKO Mice Cell cycle control,  mitochondrial homeostasis maintenance,autophagy and cell growth regulation SIRT5 KO mice have detected defeats in the ornithine cycle.
Sirtuins Protein Family(SirtFamily) SIRT6 None None Cell cycle control,  mitochondrial homeostasis maintenance,autophagy and cell growth regulation SIRT6 KO mice die before 4 weeks of age, displaying profound abnormalities, including the premature aging syndrome and severe hypoglycemia.
Sirtuins Protein Family(SirtFamily) SIRT7 None None Cell cycle control,  mitochondrial homeostasis maintenance,autophagy and cell growth regulation SIRT7 KO mice decreased in life span, and along with cardiomyopathy.
TLRs Family TLR1 TLR1 KO Mice TLR1 cKO Mice Immunity and inflammation /
TLRs Family TLR2 TLR2 KO Mice TLR2 cKO Mice Immunity and inflammation /
TLRs Family TLR3 TLR3 KO Mice TLR3 cKO Mice Immunity and inflammation /
TLRs Family TLR4 TLR4 KO Mice TLR4 cKO Mice Immunity and inflammation /
TLRs Family TLR5 TLR5 KO Mice TLR5 cKO Mice Immunity and inflammation /
TLRs Family TLR6 TLR6 KO Mice TLR6 cKO Mice Immunity and inflammation /
TLRs Family TLR7 TLR7 KO Mice TLR7 cKO Mice Immunity and inflammation /
TLRs Family TLR8 TLR8 KO Mice TLR8 cKO Mice Immunity and inflammation /
TLRs Family TLR9 TLR9 KO Mice TLR9 cKO Mice Immunity and inflammation /
TLRs Family TLR11 TLR11 KO Mice TLR11 cKO Mice Immunity and inflammation /
TLRs Family TLR12 TLR12 KO Mice TLR12 cKO Mice Immunity and inflammation /
TLRs Family TLR13 TLR13 KO Mice TLR13 cKO Mice Immunity and inflammation /
Smad Family Smad 1 None None The regulation of cell growth, cell growth, differentiation and apoptosis, TGFβ and other signaling pathways Receptor-regulated Smads protein, a kind of protein that interacts directly with activated type I receptors and can be phosphorylated, inducing receptor-specific responses.
Smad Family Smad 2 Smad 2 KO Mice Smad 2 cKO Mice
Smad Family Smad 3 Smad 3 KO Mice Smad 3 cKO Mice
Smad Family Smad 5 None None
Smad Family Smad 8 None None
Smad Family Smad 4 None None The regulation of cell growth, cell growth, differentiation and apoptosis, TGFβ and other signaling pathways The common Smads(co-Smads), a kind of Smad protein, is the shared hetero-oligomerization partner of the receptor-regulated Smads. Lacking in shared substrate sequence SSXS, it cannot be phosphorylated by any other receptors. In mammalian cells, it binds to phosphorylated Smad 1, 2, 3, 5, and 8 to form a complex that enters the nucleus, and function as a transcription factor.
Smad Family Smad 6 None None The regulation of cell growth, cell growth, differentiation and apoptosis, TGFβ and other signaling pathways Inhibitory Smads(I-Smads), among which Smad6 inhibits the signal transduction of BMP, while Smad 7 inhibits both the signal transduction of BMP and TGF-β. Smad7 can be induced by TGF-β1, to form negative feedback loop.
Smad Family Smad 7 None None
BMP Sub-Family BMP-2(BMP-2A) None None Reproduction, bones and nerve 1)Regulates bone and cartilage formation during embryonic development.2)Regulates bone morphogenesis.3)Induces mesenchymal precursor cellsto differentiate into osteoblasts.4)Regulates the apoptosis cell signal. 5)Expressed in lung, spleen, and colon.
BMP Sub-Family BMP-3(BMP-3A) BMP-3 KO Mice BMP-3 cKO Mice Reproduction, bones and nerve 1)Regulates bone and cartilage formation.2)Functioned as chemical attractions. 3)Induces the synthesis and secretion of TGF-β1 by monocytes.  4)Expressed in lungs, ovaries and small intestine.
BMP Sub-Family BMP-3B(GDF-10) BMP-3B KO Mice BMP-3B cKO Mice Reproduction, bones and nerve 1)Induces cartilage osteogenesis.2)Expressed in cerebellum, lungs, pancreas, testicles and femur.
BMP Sub-Family BMP-4(BMP2B) None None Reproduction, bones and nerve 1)Function as developmental regulator.2)Mesoderm formation during mediation, bone induction, lower limb development, bone fracture repair, tooth development and so on. 3)Regulates the formation of  myelin sheaths . 4)Induces the formation of embryonic hematopoietic tissue.5)Expressed in lungs and kidneys.
BMP Sub-Family BMP-5 None None Reproduction, bones and nerve 1)Regulates the bone formation during embryonic development2)Expressed in lungs and liver.
BMP Sub-Family BMP-6(VGR) BMP-6 KO Mice BMP-6 cKO Mice Reproduction, bones and nerve 1)Regulates bone and cartilage formation.2)Induces mesenchymal precursor cellsto differentiate into osteoblasts.3)Higher concentration in fetal cartilage.
BMP Sub-Family BMP-7(OP-1 ) None None Reproduction, bones and nerve 1)Induces cartilage and bone formation.2)Induces the lens and glomerulus formation.3)Osteoinductive factor (OIF) of epithelial osteogenesis. 4)Regulates the steady-state internal bone environment  and calcium concentration.5)Expressed in brains, kidneys and bladder.
BMP Sub-Family BMP-8(BMP-8a, OP-2) BMP-8 KO Mice BMP-8 cKO Mice Reproduction, bones and nerve 1)Assists with the sperm development. 2)Expressed in decidual cells of uterine during pregnancy.
BMP Sub-Family BMP-8b(OP-2) None None Reproduction, bones and nerve 1)Exists solely in mice.2)Prevents the germ cells apoptosis of adult rats. 3)Expressed in placental trophoblast cells.
BMP Sub-Family BMP-9(GDF-2) BMP-9 KO Mice BMP-9 cKO Mice Reproduction, bones and nerve 1)Induces mesenchymal precursor cells to differentiate into osteoblasts.2)A hormone that promotes blood production. 3)Acts on liver reticuloendothelial tissue and nerve system.
BMP Sub-Family BMP-10 None None Reproduction, bones and nerve Mediates the development of heart.
BMP Sub-Family BMP-11(GDF-11) None None Reproduction, bones and nerve Promotes the development of mesoderm and nerve tissue during embryonic development.
BMP Sub-Family BMP-12(GDF-7, CDMP-3) None None Reproduction, bones and nerve 1)Induces cartilage formation.2)Promotes the formation of tendon and  ligament,and repair after injury.
BMP Sub-Family BMP-13( GDF-6, CDMP-2) BMP-13 KO Mice BMP-13 cKO Mice Reproduction, bones and nerve 1)Induces cartilage formation.2)Promotes the formation of tendon and  ligament,and repair after injury.3)Expressed in long bones.
BMP Sub-Family BMP-14( GDF-6, CDMP-2) None None Reproduction, bones and nerve 1)Induces cartilage formation.2)Improves the healing of tendon and bone formation.3)The neurotrophic factor (BDNF) of dopaminergic neurons.4)Expressed in long bones.
BMP Sub-Family BMP-15(GDF-9B) None None Reproduction, bones and nerve Promotes the ovarian development.
BMP Sub-Family GDF-1 None None Reproduction, bones and nerve Plays a role in the mediation of cell differentation during embryonic development.
BMP Sub-Family GDF-3(Vgr-2) None None Reproduction, bones and nerve A marker of embryonic cancer stem cells in vitro and in vivo.
BMP Sub-Family GDF-8 GDF-8 KO Mice GDF-8 cKO Mice Reproduction, bones and nerve Regulates the skeletal muscle mass.
BMP Sub-Family GDF-9 None None Reproduction, bones and nerve Necessary for normal follicular growth.
BMP Sub-Family GDF-15 GDF-15KO Mice GDF-15cKO Mice Reproduction, bones and nerve The placenta controls the possible mediating factors in embryonic development.Act as an autocrine regulator.
BMP Sub-Family GDNF None None Reproduction, bones and nerve Promotes dopamine uptake. Promotes the survival and morphology differentiation of midbrain dopamine (DA) neurons.
BMP Sub-Family AMH None None Reproduction, bones and nerve Induces the degeneration of Muellerian duct.Inhibits the growth of cancer tissue derived from the Muellerian ducts.
ErbB Gene Family EGFR(ErbB1) EGFR KO Mice EGFR cKO Mice Tumor (Cancer) EGFR is the most important "targets" for targeted cancer therapy. EFGR mutation can impact the effectiveness of various targeted therapies to a great extent.
ErbB Gene Family HER2(ErbB2) None None Tumor (Cancer) HER2 gene is a significant biomarker in breast and gastric cancer-targeted therapy.
ErbB Gene Family ErbB3 None None Tumor (Cancer) /
ErbB Gene Family ErbB4 None None Tumor (Cancer) /
TP53 Family TP53(P53) TP53 KO Mice TP53 cKO Mice Cancer, development, nerve,immunity, inflammation, etc P53 is essential for preventing normal cells from turning into cancer cells, it has been nicknamed the "guardian of the genome."
TP53 Family TP63 TP63 KO Mice TP63cKO Mice Cancer, development, nerve,immunity, inflammation, etc Responsible for limb formation and differentiation of stratified epithelia during embryogenesis.The main regulator for female fertility.
TP53 Family TP73 None None Cancer, development, nerve,immunity, inflammation, etc Promotes the mature of hippocampus, cortex in brain and immune system. The main regulator for female fertility.
Ras Family K-ras None None Tumor (Cancer) Among ras genes, K-Ras has the greatest effect on human cancer. In different types of tumors, the mutation rate of the ras gene varies widely. KRAS mutations are observed in 30% of lung adenocarcinoma, 50% of colon cancer and 70%-90% of pancreatic cancer.
Ras Family N-ras None None Tumor (Cancer) The mutation rate of N-ras gene on colon cancer and other carcinomas is relatively low, but N-ras mutation can be observed in about 20%-30% of acute non-lymphocytic leukemia.
Ras Family H-ras None None Tumor (Cancer) H-ras mutation only found in a few cancers, which is commonly observed in bladder cancer with mutation rate of 10%.
Myc Family C-Myc None None Tumor (Cancer) C-myc gene is related to various tumorigenesis and development.The variation of C-myc expression is related to the state of cell proliferation and differentiation, its expression product plays a role in regulating cell growth, differentiation or malignant transformation.
Myc Family N-Myc None None Tumor (Cancer) The proto-oncogene N-Myc is expressed at the embryo stage, which plays an essential role during embryonic development, and it is involved in the regulation of various cell processes in organogenesis.
Myc Family L-Myc L-Myc KO Mice L-Myc cKO Mice Tumor (Cancer) The over-expression of L-Myc can directly impact the cell differentation, while with weak effects on cell growth, apoptosis and transformation.
FGF Family FGF-21 FGF-21 KO Mice FGF-21 cKO Mice Metabolism, bones and cancer development, embryogenesis etc FGF-21 is closely related to the occurrence and development of diabetes and its complications.
FGF Family FGF1(aFGF) FGF1KO Mice FGF1cKO Mice Metabolism, bones and cancer development, embryogenesis etc FGF1 and FGF2  on the same receptor through a series of signal transduction mechanism, promote the morphogenesis of tissues and organs, damage repair, angiogenesis and nerve cell regeneration effect, thereby increasing the survival and growth of mesodermal and neuroectodermal tissue cells (such as fiber cells, vascular endothelial cells, nerve cells ans so on).
FGF Family FGF2(bFGF) FGF2KO Mice FGF2cKO Mice
FGF Family FGF3(Int2) FGF3KO Mice FGF3cKO Mice Metabolism, bones and cancer development, embryogenesis etc Bone development
FGF Family FGF4 (hst /KFGF) FGF4KO Mice FGF4cKO Mice Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF5 FGF5KO Mice FGF5cKO Mice Metabolism, bones and cancer development, embryogenesis etc FGF5 was identified as oncogene when first discovered.
FGF Family FGF7(KGF) FGF7KO Mice FGF7cKO Mice Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF8 None None Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF9 None None Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF10 None None Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF11 None None Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF12 FGF12 KO Mice FGF12 cKO Mice Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF13 None None Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF14 FGF14 KO Mice FGF14 cKO Mice Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF15 FGF15 KO Mice FGF15 cKO Mice Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF16 None None Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF17 FGF17 KO Mice FGF17 cKO Mice Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF18 None None Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF19 None None Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF20 FGF20 KO Mice FGF20 cKO Mice Metabolism, bones and cancer development, embryogenesis etc /
FGF Family FGF23 None None Metabolism, bones and cancer development, embryogenesis etc FGF23, as a necessary factor in regulating the phosphate levels within the body, is associated with the formation of hypophosphatemia and osteomalacia.
Atg Family(Autophagy-related proteins) ATG7 None ATG7 cKO Mice Autophagy Atg7, as the core protein of the macroautophagy system, is essential for both autophagosome and non-autographic formation. Thus, Atg7 has always been the hot topic of research.
Atg Family(Autophagy-related proteins) ATG5 None None Autophagy Atg5, a key protein in autophagosome formation, plays important role in immune system and relevant  to cancer formation.
STAT Family STAT1 None None / /
STAT Family STAT2 STAT2 KO Mice STAT2 cKO Mice / /
STAT Family STAT3 None None / STAT3 plays a critical role in the early stages of embryonic development, which related to cancer development, is the key transcription factor of IL-10 Immunosuppressive function.
STAT Family STAT4 STAT4 KO Mice STAT4 cKO Mice / /
STAT Family STAT5a STAT5a KO Mice STAT5a cKO Mice / /
STAT Family STAT5b STAT5b KO Mice STAT5b cKO Mice / /
STAT Family STAT6 STAT6 KO Mice STAT6 cKO Mice / /
IL-10 Family IL-10 IL-10 KO Mice IL-10 cKO Mice / Immunosuppressive and anti-inflammatory
IL-10 Family IL-19 IL-19 KO Mice IL-19 cKO Mice / Skin development, immune regulation
IL-10 Family IL-20 IL-20 KO Mice IL-20 cKO Mice / Skin development, inflammation, hematopoiesis
IL-10 Family IL-22 None None / Acute phase repons, innate immunity
IL-10 Family IL-24 IL-24 KO Mice IL-24 cKO Mice / Apoptosis, function of epidermis, inflammatory cascade
IL-10 Family IL-26 None None / Skin and mucous membranes immunity
IL-10 Family IL-28、IL-29 None None / Antiviral immunity
 

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