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| Gene Family | Strain | Knockout Mice | Conditional Knockout Mice | Application | Description |
|---|---|---|---|---|---|
| METTL Family (Methyltransferase) |
Mettl3 | Mettl3 KO Mice | Mettl3 cKO Mice | m6A DNA methylation | METTL3 and METTL14 in the METTL family are studied more than others.The m6A modification mediated by METTL3 plays a significant role in biorhythm, DNA damage response (DDR)，regulation of stem cell self-renewal and pluripotency, parent-zygote transformation, neuro-regulation and sex determination in drosophila, various biological processes and ontogenesis development of eukaryotes such as early embryonic development of mice. The knockout of Mettl3 can cause the death of mice embryo, and the in vivo biology function of Mettl3-mediated m6A RNA modification in tissue development is largely unknown in mammals. For germ cell-specific( (Vasa-Cre) Mettl3 knockout mice (Mettl3 cKO) model, the ablation of Mettl3 in germ cells severely inhibited spermatogonial differentiation and blocked the initiation of meiosis in mice, resulting in male infertility.Specific inactivation of Mettl3 in the central nervous system (CNS) can cause severe dyskinesia or even death in mice during lactation. |
| METTL Family (Methyltransferase) |
Mettl14 | Mettl14 KO Mice | Mettl14 cKO Mice | m6A DNA methylation | Germ cell-specific Mettl3 or Mettl14 knockout with Vasa-Cre in mice can bring the loss of m6A, then cause proliferation of spermatogonial stem cells (SSCs) and translation dysfunction of differentiation-associated gene transcript, eventually result in the depletion of spermatogonial stem cells (SSCs). Combined deletion of Mettl3 and Mettl14 will impair the translation of haploid-specific genes for spermiogenesis, and finally result in spermatogenesis arrest.Specificl inactivation of Mettl14 in central nervous system (CNS)in mice can cause severe impact on its cerebral cortical development. |
| METTL Family (Methyltransferase) |
Mettl1 | Mettl1 KO Mice | Mettl1 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl2 | Mettl2 KO Mice | Mettl2 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl5 | Mettl5 KO Mice | Mettl5 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl7a1 | Mettl17a1 KO Mice | Mettl17a1 cKO Mice | / | The expression of Methyltransferase Mettl7a1 is associated with the successful reprogramming trajectory, and adding Mettl7a1 to the reprogramming cocktail increases the yield of induced endoderm progenitors. |
| METTL Family (Methyltransferase) |
Mettl7b | Mettl7b KO Mice | Mettl7b cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl6 | Mettl6 KO Mice | Mettl6 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl8 | Mettl8 KO Mice | Mettl8 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl10 | Mettl10 KO Mice | Mettl10 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl11b | Mettl11b KO Mice | Mettl11b cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl9 | Mettl9 KO Mice | Mettl9 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl13 | Mettl13 KO Mice | Mettl13 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl15 | Mettl15 KO Mice | Mettl15 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl16 | Mettl16 KO Mice | Mettl16 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl17 | Mettl17 KO Mice | Mettl17 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl20 | Mettl20 KO Mice | Mettl20 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl21a | Mettl21a KO Mice | Mettl21a cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl21c | Mettl21c KO Mice | Mettl21c cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl21e | Mettl21e KO Mice | Mettl21e cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl22 | Mettl22 KO Mice | Mettl22 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl23 | Mettl23 KO Mice | Mettl23 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl24 | Mettl24 KO Mice | Mettl24 cKO Mice | / | / |
| METTL Family (Methyltransferase) |
Mettl25 | Mettl25 KO Mice | Mettl25 cKO Mice | / | / |
| YTHDF Family | Ythdf1 | Ythdf1 KO Mice | Ythdf1 cKO Mice | m6A DNA methylation | YTHDF Family is the most popular research object in "reader" for it participates in the translation and degradation of protein extranuclear. YTHDF1 protein, mainly binding to the m6A site of mRNA, it plays an essential role in brain development, dopamine secretion, synaptogenesis, and other processes. |
| YTHDF Family | Ythdf2 | None | Ythdf2 cKO Mice | m6A DNA methylation | YTHDF2 is the first protein being identified as the reader of m6A. YTHDF2-mediated degradation of m6A-containing mRNA is also the first aspect that known by humankind in the influence of m6A on the fate of mRNA. |
| YTHDF Family | Ythdf3 | Ythdf3 KO Mice | Ythdf3 cKO Mice | m6A DNA methylation | Together with YTHDF1 and YTHDF2, YTDHF3 plays a critic role in speeding up the metabolism of m6A-mediated mRNA in the cytoplasm. All these 3 YTHDF proteins can influence the m6A RNA DNA methylation related basic biology process through integration and collaboration. |
| NLRP Family(67) | NLRP1 | None | None | Immunity | Nucleotide-binding oligomerization domain-like receptor protein 1(NLRP1) inflammasome is a kind of protein complexes formed by the combination of molecules (such as apoptosis-related specular protein (ASC) and caspase-1 and caspase-5 precursors) and the NLRP1 after identification of intracellular pathogen-associated molecular patterns (PAMP). After activation, it promotes the maturation and release of IL-1β, IL-18, IL-33, and other inflammatory factors, and plays an important role in innate immunity. |
| NLRP Family(67) | NLRP3 | None | None | Immunity | NLRP3, as the important component of innate immunity, plays a critic role in the immune response and disease development. Overactivation of NRLP3 can induce various major human diseases, such as Alzheimer's disease (AD), inflammatory bowel disease (IBD) , diabetes and cancer. |
| NLRP Family(67) | NLRP6 | NLRP6 KO Mice | NLRP6c KO Mice | Immunity | NLRP6, short for the NOD-like receptor family pyrin domain containing 6, is a protein with a unique function in the NLRs family. NLRP6 is highly expressed in intestine, which can inhibit inflammation and repair damaged intestine. According to research, its deficient expression with inflamed colon and colorectal cancer indicates that NLPR6 could be the potential new targeting treatment of cancer for its function in promoting apoptosis and preventing tumor development. |
| NLRP Family(67) | NLRP10 | NLRP10 KO Mice | NLRP10c KO Mice | Immunity | NLRP10 can promotes the NOD1 mediated immune reponse as well as inhibit the activation of NLRP3 inflammasome. |
| NLRP Family(67) | NLRP12 | NLRP12 KO Mice | NLRP12 cKO Mice | Immunity | Some research showed that NLPR12 is closely associated with inflammatory bowel disease (IBD), and it may play a dual function in the development of enteritis. Increased colonic inflammation and antimicrobial peptide production in Nlrp12-/- mice may promote dysbacteriosis. After high-fat feeding, Nlrp12 mice display dysbiosis marked by increased obesity-associated Erysipelotrichaceae, but reduced lachnospiraceae and clostridium required for short-chain fatty acid (SCFA) synthesis. |
| NLRP Family(67) | NLRP2 | NLRP2 KO Mice | NLRP2 cKO Mice | Reproduction | Nlrp2 is required for early embryonic development in the mouse. |
| NLRP Family(67) | NLRP4 | NLRP4a、NLRP4b、NLRP4f KO Mice | NLRP4a、NLRP4b、NLRP4e、NLRP4f cKO Mice | Reproduction | NLRP4 in mice has been duplicated during gene evolution, total of 7 genes from Nlrp4a to Nlrp4g were identified so far. Studies have shown that these 7 Nlrp4 genes have similar expression profiles, which are expressed in oocytes and early embryos in the mouse, while NLRP4 protein does not affect the process of oocyte maturation, but mainly plays a role in early embryonic development. |
| NLRP Family(67) | NLRP5 | NLRP5 KO Mice | NLRP5 cKO Mice | Reproduction | NLPR5 plays a vital role in the early embryonic development of mice. |
| NLRP Family(67) | NLRP7 | / | / | Reproduction | The human NLRP7 gene is expressed in oocytes and early embryos. Gene mutation cause changes in the encoded protein, and furtherly leading to abnormal development in the earlier human embryonic period. |
| NLRP Family(67) | NLRP8 | / | / | Reproduction | / |
| NLRP Family(67) | NLRP9 | NLRP9 KO Mice | NLRP9 cKO Mice | Reproduction | NLRP9b model available |
| NLRP Family(67) | NLRP11 | / | / | Reproduction | / |
| NLRP Family(67) | NLRP13 | / | / | Reproduction | / |
| NLRP Family(67) | NLRP14 | NLRP14 KO Mice | NLRP14 cKO Mice | Reproduction | The silencing of the NLRP14 gene from zygotes is known to generate various degrees of developmental arrest during early embryogenesis and cause developmental failure. Besides, the NLRP14 gene also expresses in the sperms of humans and mouse, the mutation of this gene in the human will cause spermatogenic failure. If NLRP14 mutation happens on humans, it will lead to Infertility. |
| Sirtuins Protein Family(SirtFamily) | SIRT1 | None | None | Cell cycle control, mitochondrial homeostasis maintenance,autophagy and cell growth regulation | Majority of SIRT1 KO mice died before and after birth, with retinal, bone and heart defects detected. |
| Sirtuins Protein Family(SirtFamily) | SIRT3 | SIRT3 KO Mice | SIRT3 cKO Mice | Cell cycle control, mitochondrial homeostasis maintenance,autophagy and cell growth regulation | SIRT3KO mice developed normally, the AceCS2 activity, ATP level, and acetylation of mitochondrial proteins changed. |
| Sirtuins Protein Family(SirtFamily) | SIRT4 | SIRT4 KO Mice | SIRT4 cKO Mice | Cell cycle control, mitochondrial homeostasis maintenance,autophagy and cell growth regulation | SIRT4KO mice developed normally, mitochondrial GDH activity increased. |
| Sirtuins Protein Family(SirtFamily) | SIRT5 | SIRT5 KO Mice | SIRT5 cKO Mice | Cell cycle control, mitochondrial homeostasis maintenance,autophagy and cell growth regulation | SIRT5 KO mice have detected defeats in the ornithine cycle. |
| Sirtuins Protein Family(SirtFamily) | SIRT6 | None | None | Cell cycle control, mitochondrial homeostasis maintenance,autophagy and cell growth regulation | SIRT6 KO mice die before 4 weeks of age, displaying profound abnormalities, including the premature aging syndrome and severe hypoglycemia. |
| Sirtuins Protein Family(SirtFamily) | SIRT7 | None | None | Cell cycle control, mitochondrial homeostasis maintenance,autophagy and cell growth regulation | SIRT7 KO mice decreased in life span, and along with cardiomyopathy. |
| TLRs Family | TLR1 | TLR1 KO Mice | TLR1 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR2 | TLR2 KO Mice | TLR2 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR3 | TLR3 KO Mice | TLR3 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR4 | TLR4 KO Mice | TLR4 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR5 | TLR5 KO Mice | TLR5 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR6 | TLR6 KO Mice | TLR6 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR7 | TLR7 KO Mice | TLR7 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR8 | TLR8 KO Mice | TLR8 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR9 | TLR9 KO Mice | TLR9 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR11 | TLR11 KO Mice | TLR11 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR12 | TLR12 KO Mice | TLR12 cKO Mice | Immunity and inflammation | / |
| TLRs Family | TLR13 | TLR13 KO Mice | TLR13 cKO Mice | Immunity and inflammation | / |
| Smad Family | Smad 1 | None | None | The regulation of cell growth, cell growth, differentiation and apoptosis, TGFβ and other signaling pathways | Receptor-regulated Smads protein, a kind of protein that interacts directly with activated type I receptors and can be phosphorylated, inducing receptor-specific responses. |
| Smad Family | Smad 2 | Smad 2 KO Mice | Smad 2 cKO Mice | ||
| Smad Family | Smad 3 | Smad 3 KO Mice | Smad 3 cKO Mice | ||
| Smad Family | Smad 5 | None | None | ||
| Smad Family | Smad 8 | None | None | ||
| Smad Family | Smad 4 | None | None | The regulation of cell growth, cell growth, differentiation and apoptosis, TGFβ and other signaling pathways | The common Smads(co-Smads), a kind of Smad protein, is the shared hetero-oligomerization partner of the receptor-regulated Smads. Lacking in shared substrate sequence SSXS, it cannot be phosphorylated by any other receptors. In mammalian cells, it binds to phosphorylated Smad 1, 2, 3, 5, and 8 to form a complex that enters the nucleus, and function as a transcription factor. |
| Smad Family | Smad 6 | None | None | The regulation of cell growth, cell growth, differentiation and apoptosis, TGFβ and other signaling pathways | Inhibitory Smads(I-Smads), among which Smad6 inhibits the signal transduction of BMP, while Smad 7 inhibits both the signal transduction of BMP and TGF-β. Smad7 can be induced by TGF-β1, to form negative feedback loop. |
| Smad Family | Smad 7 | None | None | ||
| BMP Sub-Family | BMP-2(BMP-2A) | None | None | Reproduction, bones and nerve | 1)Regulates bone and cartilage formation during embryonic development.2)Regulates bone morphogenesis.3)Induces mesenchymal precursor cellsto differentiate into osteoblasts.4)Regulates the apoptosis cell signal. 5)Expressed in lung, spleen, and colon. |
| BMP Sub-Family | BMP-3(BMP-3A) | BMP-3 KO Mice | BMP-3 cKO Mice | Reproduction, bones and nerve | 1)Regulates bone and cartilage formation.2)Functioned as chemical attractions. 3)Induces the synthesis and secretion of TGF-β1 by monocytes. 4)Expressed in lungs, ovaries and small intestine. |
| BMP Sub-Family | BMP-3B(GDF-10) | BMP-3B KO Mice | BMP-3B cKO Mice | Reproduction, bones and nerve | 1)Induces cartilage osteogenesis.2)Expressed in cerebellum, lungs, pancreas, testicles and femur. |
| BMP Sub-Family | BMP-4(BMP2B) | None | None | Reproduction, bones and nerve | 1)Function as developmental regulator.2)Mesoderm formation during mediation, bone induction, lower limb development, bone fracture repair, tooth development and so on. 3)Regulates the formation of myelin sheaths . 4)Induces the formation of embryonic hematopoietic tissue.5)Expressed in lungs and kidneys. |
| BMP Sub-Family | BMP-5 | None | None | Reproduction, bones and nerve | 1)Regulates the bone formation during embryonic development2)Expressed in lungs and liver. |
| BMP Sub-Family | BMP-6(VGR) | BMP-6 KO Mice | BMP-6 cKO Mice | Reproduction, bones and nerve | 1)Regulates bone and cartilage formation.2)Induces mesenchymal precursor cellsto differentiate into osteoblasts.3)Higher concentration in fetal cartilage. |
| BMP Sub-Family | BMP-7(OP-1 ) | None | None | Reproduction, bones and nerve | 1)Induces cartilage and bone formation.2)Induces the lens and glomerulus formation.3)Osteoinductive factor (OIF) of epithelial osteogenesis. 4)Regulates the steady-state internal bone environment and calcium concentration.5)Expressed in brains, kidneys and bladder. |
| BMP Sub-Family | BMP-8(BMP-8a, OP-2) | BMP-8 KO Mice | BMP-8 cKO Mice | Reproduction, bones and nerve | 1)Assists with the sperm development. 2)Expressed in decidual cells of uterine during pregnancy. |
| BMP Sub-Family | BMP-8b(OP-2) | None | None | Reproduction, bones and nerve | 1)Exists solely in mice.2)Prevents the germ cells apoptosis of adult rats. 3)Expressed in placental trophoblast cells. |
| BMP Sub-Family | BMP-9(GDF-2) | BMP-9 KO Mice | BMP-9 cKO Mice | Reproduction, bones and nerve | 1)Induces mesenchymal precursor cells to differentiate into osteoblasts.2)A hormone that promotes blood production. 3)Acts on liver reticuloendothelial tissue and nerve system. |
| BMP Sub-Family | BMP-10 | None | None | Reproduction, bones and nerve | Mediates the development of heart. |
| BMP Sub-Family | BMP-11(GDF-11) | None | None | Reproduction, bones and nerve | Promotes the development of mesoderm and nerve tissue during embryonic development. |
| BMP Sub-Family | BMP-12(GDF-7, CDMP-3) | None | None | Reproduction, bones and nerve | 1)Induces cartilage formation.2)Promotes the formation of tendon and ligament，and repair after injury. |
| BMP Sub-Family | BMP-13( GDF-6, CDMP-2) | BMP-13 KO Mice | BMP-13 cKO Mice | Reproduction, bones and nerve | 1)Induces cartilage formation.2)Promotes the formation of tendon and ligament，and repair after injury.3)Expressed in long bones. |
| BMP Sub-Family | BMP-14( GDF-6, CDMP-2) | None | None | Reproduction, bones and nerve | 1)Induces cartilage formation.2)Improves the healing of tendon and bone formation.3)The neurotrophic factor (BDNF) of dopaminergic neurons.4)Expressed in long bones. |
| BMP Sub-Family | BMP-15(GDF-9B) | None | None | Reproduction, bones and nerve | Promotes the ovarian development. |
| BMP Sub-Family | GDF-1 | None | None | Reproduction, bones and nerve | Plays a role in the mediation of cell differentation during embryonic development. |
| BMP Sub-Family | GDF-3(Vgr-2) | None | None | Reproduction, bones and nerve | A marker of embryonic cancer stem cells in vitro and in vivo. |
| BMP Sub-Family | GDF-8 | GDF-8 KO Mice | GDF-8 cKO Mice | Reproduction, bones and nerve | Regulates the skeletal muscle mass. |
| BMP Sub-Family | GDF-9 | None | None | Reproduction, bones and nerve | Necessary for normal follicular growth. |
| BMP Sub-Family | GDF-15 | GDF-15KO Mice | GDF-15cKO Mice | Reproduction, bones and nerve | The placenta controls the possible mediating factors in embryonic development.Act as an autocrine regulator. |
| BMP Sub-Family | GDNF | None | None | Reproduction, bones and nerve | Promotes dopamine uptake. Promotes the survival and morphology differentiation of midbrain dopamine (DA) neurons. |
| BMP Sub-Family | AMH | None | None | Reproduction, bones and nerve | Induces the degeneration of Muellerian duct.Inhibits the growth of cancer tissue derived from the Muellerian ducts. |
| ErbB Gene Family | EGFR(ErbB1) | EGFR KO Mice | EGFR cKO Mice | Tumor (Cancer) | EGFR is the most important "targets" for targeted cancer therapy. EFGR mutation can impact the effectiveness of various targeted therapies to a great extent. |
| ErbB Gene Family | HER2(ErbB2) | None | None | Tumor (Cancer) | HER2 gene is a significant biomarker in breast and gastric cancer-targeted therapy. |
| ErbB Gene Family | ErbB3 | None | None | Tumor (Cancer) | / |
| ErbB Gene Family | ErbB4 | None | None | Tumor (Cancer) | / |
| TP53 Family | TP53(P53) | TP53 KO Mice | TP53 cKO Mice | Cancer, development, nerve,immunity, inflammation, etc | P53 is essential for preventing normal cells from turning into cancer cells, it has been nicknamed the "guardian of the genome." |
| TP53 Family | TP63 | TP63 KO Mice | TP63cKO Mice | Cancer, development, nerve,immunity, inflammation, etc | Responsible for limb formation and differentiation of stratified epithelia during embryogenesis.The main regulator for female fertility. |
| TP53 Family | TP73 | None | None | Cancer, development, nerve,immunity, inflammation, etc | Promotes the mature of hippocampus, cortex in brain and immune system. The main regulator for female fertility. |
| Ras Family | K-ras | None | None | Tumor (Cancer) | Among ras genes, K-Ras has the greatest effect on human cancer. In different types of tumors, the mutation rate of the ras gene varies widely. KRAS mutations are observed in 30% of lung adenocarcinoma, 50% of colon cancer and 70%-90% of pancreatic cancer. |
| Ras Family | N-ras | None | None | Tumor (Cancer) | The mutation rate of N-ras gene on colon cancer and other carcinomas is relatively low, but N-ras mutation can be observed in about 20%-30% of acute non-lymphocytic leukemia. |
| Ras Family | H-ras | None | None | Tumor (Cancer) | H-ras mutation only found in a few cancers, which is commonly observed in bladder cancer with mutation rate of 10%. |
| Myc Family | C-Myc | None | None | Tumor (Cancer) | C-myc gene is related to various tumorigenesis and development.The variation of C-myc expression is related to the state of cell proliferation and differentiation, its expression product plays a role in regulating cell growth, differentiation or malignant transformation. |
| Myc Family | N-Myc | None | None | Tumor (Cancer) | The proto-oncogene N-Myc is expressed at the embryo stage, which plays an essential role during embryonic development, and it is involved in the regulation of various cell processes in organogenesis. |
| Myc Family | L-Myc | L-Myc KO Mice | L-Myc cKO Mice | Tumor (Cancer) | The over-expression of L-Myc can directly impact the cell differentation, while with weak effects on cell growth, apoptosis and transformation. |
| FGF Family | FGF-21 | FGF-21 KO Mice | FGF-21 cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | FGF-21 is closely related to the occurrence and development of diabetes and its complications. |
| FGF Family | FGF1(aFGF) | FGF1KO Mice | FGF1cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | FGF1 and FGF2 on the same receptor through a series of signal transduction mechanism, promote the morphogenesis of tissues and organs, damage repair, angiogenesis and nerve cell regeneration effect, thereby increasing the survival and growth of mesodermal and neuroectodermal tissue cells (such as fiber cells, vascular endothelial cells, nerve cells ans so on). |
| FGF Family | FGF2(bFGF) | FGF2KO Mice | FGF2cKO Mice | ||
| FGF Family | FGF3(Int2) | FGF3KO Mice | FGF3cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | Bone development |
| FGF Family | FGF4 (hst /KFGF) | FGF4KO Mice | FGF4cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF5 | FGF5KO Mice | FGF5cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | FGF5 was identified as oncogene when first discovered. |
| FGF Family | FGF7(KGF) | FGF7KO Mice | FGF7cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF8 | None | None | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF9 | None | None | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF10 | None | None | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF11 | None | None | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF12 | FGF12 KO Mice | FGF12 cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF13 | None | None | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF14 | FGF14 KO Mice | FGF14 cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF15 | FGF15 KO Mice | FGF15 cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF16 | None | None | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF17 | FGF17 KO Mice | FGF17 cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF18 | None | None | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF19 | None | None | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF20 | FGF20 KO Mice | FGF20 cKO Mice | Metabolism, bones and cancer development, embryogenesis etc | / |
| FGF Family | FGF23 | None | None | Metabolism, bones and cancer development, embryogenesis etc | FGF23, as a necessary factor in regulating the phosphate levels within the body, is associated with the formation of hypophosphatemia and osteomalacia. |
| Atg Family(Autophagy-related proteins) | ATG7 | None | ATG7 cKO Mice | Autophagy | Atg7, as the core protein of the macroautophagy system, is essential for both autophagosome and non-autographic formation. Thus, Atg7 has always been the hot topic of research. |
| Atg Family(Autophagy-related proteins) | ATG5 | None | None | Autophagy | Atg5, a key protein in autophagosome formation, plays important role in immune system and relevant to cancer formation. |
| STAT Family | STAT1 | None | None | / | / |
| STAT Family | STAT2 | STAT2 KO Mice | STAT2 cKO Mice | / | / |
| STAT Family | STAT3 | None | None | / | STAT3 plays a critical role in the early stages of embryonic development, which related to cancer development, is the key transcription factor of IL-10 Immunosuppressive function. |
| STAT Family | STAT4 | STAT4 KO Mice | STAT4 cKO Mice | / | / |
| STAT Family | STAT5a | STAT5a KO Mice | STAT5a cKO Mice | / | / |
| STAT Family | STAT5b | STAT5b KO Mice | STAT5b cKO Mice | / | / |
| STAT Family | STAT6 | STAT6 KO Mice | STAT6 cKO Mice | / | / |
| IL-10 Family | IL-10 | IL-10 KO Mice | IL-10 cKO Mice | / | Immunosuppressive and anti-inflammatory |
| IL-10 Family | IL-19 | IL-19 KO Mice | IL-19 cKO Mice | / | Skin development, immune regulation |
| IL-10 Family | IL-20 | IL-20 KO Mice | IL-20 cKO Mice | / | Skin development, inflammation, hematopoiesis |
| IL-10 Family | IL-22 | None | None | / | Acute phase repons, innate immunity |
| IL-10 Family | IL-24 | IL-24 KO Mice | IL-24 cKO Mice | / | Apoptosis, function of epidermis, inflammatory cascade |
| IL-10 Family | IL-26 | None | None | / | Skin and mucous membranes immunity |
| IL-10 Family | IL-28、IL-29 | None | None | / | Antiviral immunity |