수술 & 질환 모델 동물 서비스

Overview: Cyagen Small Animal Surgical & Disease Model Services

In view of this situation, Cyagen has utilized years’ of accumulated experience in efficient team building and management to successfully build a mature mouse surgical model service team after 2 years’ preparation. Cyagen’s team has developed rigorous standards in the production and construction of various models - establishing complex and compound surgical disease models. We take “Repeatable” as our service standard. For complex project requirements or disease models not or rarely seen in the literature, we will work closely with clients to carefully understand their research needs and develop the appropriate surgical model construction scheme. We truly hope our professionally-standardized surgical model services will save your time and energy - enabling you to achieve results on innovative research project(s).

In view of this situation, Cyagen has utilized years’ of accumulated experience in efficient team building and management to successfully build a mature mouse surgical model service team after 2 years’ preparation. Cyagen’s team has developed rigorous standards in the production and construction of various models - establishing complex and compound surgical disease models. We take “Repeatable” as our service standard. For complex project requirements or disease models not or rarely seen in the literature, we will work closely with clients to carefully understand their research needs and develop the appropriate surgical model construction scheme. We truly hope our professionally-standardized surgical model services will save your time and energy - enabling you to achieve results on innovative research project(s).

Our Advantages

• 1. Take “Repeatable”as the service standard
  We take “Repeatable” as our gold standard: our technical team is thoroughly trained in surgical model operations to ensure the data stability of every model, even across different batches.
• 2. One-stop service: Save time and energy
  Some custom animal models require a combination of gene modification, surgical modelling, and physical stimulation/drug induction to achieve the desired phenotype. Our professional surgical model team works with our highly-developed genome-editing, breeding, and cryopreservation platforms to accomplish the most complicated model generation projects. Cyagen provides a one-stop service for all your small animal model generation and support needs, including: "Genome-editing Mouse Model Construction/Generation - Population Propagation - Surgical Modelling - Phenotypic Validation” - saving you time and energy.
• 3. Professional Technical Support
  Cyagen’s small animal surgical team are skilled across various model generation techniques, including complex and compound surgical disease model establishment. We provide technical information throughout the process to cater to your needs, from model generation proposals and up-to-date project reports, all the way to after-sales services – ensuring that you have everything you need for experimental success.
• 4. Complying to international animal welfare and quality standards with double accreditation of AAALAC and ISO9001: 2015
  The Cyagen Transgenic Animal Center (CTAC) has passed the double accreditation of ISO9001:2015 and AAALAC. All of our products and technical services provided to experts and scientists consistently meet the international standards for quality, as signified by ISO9001:2015. Our AAALAC accreditation demonstrates that Cyagen Biosciences upholds respectful practices in animal welfare and ethics as part of our rigorous bio-safety standards.

Chief Scientist of Cyagen Surgical Disease Models

Dr. Rongli Zhang
Dr. Rongli Zhang has more than 20 years of experience in creating mouse surgical models. Prior to Cyagen, Dr. Zhang was employed by China Academy of Chinese Medical Science (CACMS), Tsinghua University (THU), Peking University (PKU) and internationally renowned academic institutions successively after PhD. He worked in Case Western Reserve University in U.S since 2011 as both a research scientist and director of Cardiovascular Physiology Laboratory, in charge of the discovery of disease phenotype in genetically engineered animals and preclinical drug development.

In addition, he has done many preclinical pharmacology studies for famous domestic and worldwide pharmaceutical enterprises - helping these companies achieve successful product launches. Dr. Zhang has finished 10 projects during his work in China, and took part in multiple fund programs in the U.S. supported by both the NIH (National Institutes of Health) and AHA (American Heart Association). He has 60 publications in SCI journals, with many articles published in high-impact academic journals (such as Nature, Proceedings of the National Academy of Sciences, Journal of Clinical Investigation, Circulation, Cell, Nature Communications, and Science Translational Medicine).

Case Study

1. Myocardial Infarction Model (Left Coronary Artery Ligation), Ischemia/Reperfusion Model (MIRI)

2. Transverse Aortic Constriction (TAC)

3. Chronic Heart Failure (CHF）