Cyagen의 전문가가 프로젝트 요구 사항에 대한
견적,
정보 및 예상 소요시간을 제공해 드릴 것
입니다.
면역결핍 마우스는 선천적인 유전자 돌연변이나 인위적인 방법으로 면역체계에서 하나 이상의 면역세포(B세포, T세포, NK세포 등)에 결함이나 결손이 있는 마우스 모델을 말합니다. 유전자 편집 기술이 발달하면서 새로 개발된 면역 결함 마우스의 strains는 지속적으로 증가하고 있습니다. 면역 결핍 마우스 모델은 종양학(종양 성장, 전이, 항종양 약물 스크리닝 등), 면역학(면역 세포 발달 및 증식 메커니즘, 면역 질환 발생 메커니즘 등), 역학(바이러스/세균 감염성 질환 발병 기전), 줄기세포 생물학(인간 줄기세포 이식) 등 연구 분야에서 널리 사용됩니다. 이 중 중증 면역결핍 마우스(T Cell, B Cell 및 NK 면역 세포 결핍) 모델에는 인간 조혈모세포(HSCs), 인간 말초 혈액 단핵세포(PBMCs), 인간 종양 세포주 유래 이종 이식(CDX), 환자 종양 조직 유래 이종 이식(PDX) 또는 기타 성체줄기세포(Adult stem cells) 및 조직을 효율적으로 이식할 수 있으며, 인간화 마우스 모델 구축에 널리 사용됩니다.
Cyagen의 약물 스크리닝 및 약물 평가 마우스 모델 플랫폼은 NKG, Rag1 KO, Rag2 KO, Tcra KO 등 다양한 유형의 면역결핍 마우스 모델을 제공하여 신약 연구·개발을 지원합니다.
| 제품 번호 | 모델명 | 품종 계통 | 응용 분야 |
|---|---|---|---|
|
C001416 |
NKG |
Graft-versus-host disease (GvHD); The immune system; Hematopoietic system; Blood disease; Cell line-derived xenograft (CDX); Patient-derived xenograft (PDX). (Significantly delayed the onset of GvHD.) |
|
|
C001498 |
NKG |
Establishment of humanized mouse models for the immune system; research on graft-versus-host disease (GvHD) in xenotransplantation; research on the immune system, hematopoietic system, and blood disorders; xenotransplantation of human cell lines (CDX), patient tumor tissue xenotransplantation (PDX), and drug screening and efficacy evaluation. |
|
|
C001513 |
NKG |
Severe immunodeficiency second-generation mice, effectively reconstruct NK cells. |
|
|
C001197 |
C57BL/6NCya |
Research on immune system-related diseases; Establishment of tumor-bearing models; Immune system deficiency; Cancer; Toxicology and other related research |
|
|
C001324 |
C57BL/6JCya |
Research on immune system-related diseases; Establishment of tumor-bearing models; Immune system deficiency; Cancer; Toxicology and other related research |
|
|
C001332 |
C57BL/6JCya |
Immunology; Inflammation; Autoimmunity research |
|
|
C001342 |
C57BL/6JCya |
Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research |
|
|
C001343 |
BALB/c |
Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research |
|
|
C001340 |
C57BL/6JCya |
Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research |
|
|
C001341 |
BALB/c |
Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research |
|
|
C001344 |
C57BL/6JCya |
Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research |
|
|
C001345 |
BALB/c |
Immunology; Inflammation; Autoimmunity research; B cell deletion and other related research |
|
|
C001436 |
Balb/c |
Oncology; Immunology; Infectious Disease; Stem Cell Biology; and related research. |
|
|
I001176 |
NKG |
Construction of humanized mouse models with an immune system; Research on the human immune system and hematopoietic system; Xenotransplantation of human cell lines (CDX) and drug screening and efficacy evaluation; Xenotransplantation of patient-derived tumor tissues (PDX) and drug screening and efficacy evaluation. |
|
|
C001559 |
NKG |
Highly effective in delaying the occurrence of GvHD (graft-versus-host disease) |
|
|
C001550 |
C57BL/6NCya |
Lambda type B cell deficiency |
|
|
I001125 |
129S2/SvPasCya |
Research on the pathogenesis of arthropod-borne viruses such as Dengue virus (DENV), Zika virus (ZIKV), Yellow fever virus (YFV), and Chikungunya virus (CHIKV), as well as the development of preventive vaccines; studies on antiviral immune responses, interferon stimulation, and JAK-STAT signaling pathways. |
|
|
C001215 |
C57BL/6JCya |
Hematopoietic regulation research; pathological research on myeloid leukemia; research on the mechanisms of atherosclerosis; research on the regulation of immune and inflammatory responses; other hematological tumor research. |
|
|
C001367 |
C57BL/6JCya |
Research related to immune system deficiencies, cancer, toxicology, and xenotransplantation. |
|
|
C001374 |
C57BL/6JCya |
Oncology: research on tumor growth, metastasis, and screening of anti-tumor drugs; Immunology: research on the mechanisms of immune cell development and proliferation, and the pathogenesis of immune diseases; Infectious Diseases: research on the pathogenic mechanisms of viral and bacterial infections; Stem Cell Biology: research on human-derived stem cell transplantation. |
|
|
I001126 |
C57BL/6JCya |
Human liver regeneration and reconstruction, liver biology, and liver-related drug research. |
|
|
IR1023 |
SD |
Immunodeficient rats with deficiencies in T cells, B cells, and NK cells. |
|
|
I001199 |
129S2/SvPasCya |
Research on the pathogenesis of arthropod-borne viruses and the development of preventive vaccines, as well as antiviral immune responses. |
|
|
I001200 |
129S2/SvPasCya |
Research on the pathogenesis of arthropod-borne viruses and the development of preventive vaccines, as well as antiviral immune responses. |
|
|
I001175 |
NKG |
Construction of humanized mouse models of the immune system; Research on the human immune system and hematopoietic system; Human cell line xenografts (CDX) for drug screening and efficacy evaluation; Patient-derived tumor xenografts (PDX) for drug screening and efficacy evaluation. |
|
|
I001177 |
NKG |
Construction of humanized mouse models of the immune system; Research on the human immune system and hematopoietic system; Human cell line xenografts (CDX) for drug screening and efficacy evaluation; Patient-derived tumor xenografts (PDX) for drug screening and efficacy evaluation. |
|
|
C001213 |
C57BL/6NCya |
Immune Cells and Systems Research, Autoimmune Disease Research |
|
|
C001214 |
C57BL/6NCya |
Immune System-Related Research |
|
|
C001390 |
C57BL/6JCya |
IgG1 Deficiency Diseases |
|
|
C001394 |
C57BL/6JCya |
Selective Immunoglobulin A (IgA) Deficiency |
|
|
C001585 |
C57BL/6NCya |
Neutrophil function and anti-bacterial and anti-fungal infections; Preparation of anti-mouse MPO auto-antibodies |
|
|
CR005 |
Sprague-Dawley |
|
|
|
C001695 |
NKG |
|
Cyagen 은 다양한 약물 평가 모델과 표현형 분석 서비스를 제공하여 프로젝트에 안정적이고 편리한 데이터 보고를 제공합니다.
Cyagen 동물 주문에 대한 아래 지원 정보를 참조하십시오.
(https://www.cyagen.com/us/en/support/order-information.html)
Cyagen은 무료 상담 제공합니다! 프로젝트 문의 또는 견적 요청을 원하시면, 문의 양식을 제출하시거나 이메일(service-apac@cyagen.com)로 연락해 주시면, 신속한 답변을 드리겠습니다.