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죽상동맥경화증 유전자 변형 마우스 모델

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Apoe 및 LDL-R 유전자 knock-out 마우스는 동맥경화성 플라크가 자발적으로 형성되며, 죽상동맥경화증 연구에서 자주 사용되는 모델이다.

1. ApoE Knockout Mice

Genetic Background: C57BL/6 Background

Origin: The model was created by targeting the Apoe gene in E14TG2a ES cells and injecting the targeted cells into C57BL/6J blastocysts. Resultant chimeras were backcrossed for ten generations (N10) and intercrossed to homozygosity. Taconic received stock in May 1998 and backcrossed one additional generation (N11). The line was derived by embryo transfer and is maintained by incrossing homozygous mice.

Genetics: Nnt 돌연변이의 야생형이다. 이 마우스(Gpi1a 는 대립 유전자, ES1a 대립 유전자와 ES1b 대립 유전자를 가짐)는 C57BL/6N 근교계(Gpi1b 대립 유전자와 ES1a 대립 유전자를 가짐) 마우스와 대조된다.

Model Description:
●  마우스 내생 아포지질단백질 E(APOE) 유전자가 파괴되었다.
●  Homozygous ApoE knock-out(KO) 마우스는 APOE 단백질이 부족하다.
●  마우스는 정상 발육하였으나 혈청혈장콜레스테롤 수치가 정상치의 5배로 높아져 자발적인 죽상동맥경화가 발생하였다.
●  연구에 따르면 APOE는 면역체계 조절, 신경 재생 및 근육 분화에서 역할을 한다.

연구 및 응용: ApoE Knock-out 마우스는 APOE가 지질대사, 죽상동맥경화와 신경손상에서의 작용, 그리고 죽상동맥경화의 진전을 바꾸는 관여요법을 연구하는 데 도움이 된다.

Health Standard: SPF

 

2. LDLR Gene Knockout Mice

LDL수용체(low density lipoprotein receptor, LDLR) KO 마우스는 현재 동맥경화증(AS) 연구에 가장 많이 사용되는 동물이다. LDLR이 제거된 마우스는 세포가 저밀도리포단백질을 거의 흡수하지 못하기 때문에 내 환경(혈액)에서 저밀도리포단백질의 함량이 높은 수준을 유지하고 지질침윤 과정을 촉진시켜 동맥경화를 유발한다. Ldlr-/- 마우스를 이용한 연구에서 발견된 동맥경화에 의한 염증반응에서는 비만세포의 침윤이 매우 중요한 단계이며, 비만세포의 제거 또는 비만세포의 탈과립 작용은 죽상동맥경화증의 형성을 현저하게 감소시킬 수 있다. 이 성과는 죽상동맥경화증의 예방과 치료에 매우 중요한 의미를 가지고 있다.

검사항목: 체중, 음식 섭취량, 혈청생화학적검사 또는 ELISA 검사, 대동맥궁 병리적 형태 분석 등(동맥조직 H&E 염색, Oil red, 동맥내막 및 동맥내막 횡단면에서의 플라크 면적 비율 측정)

 

3. Other Genetically Modified Mouse Models Related to Atherosclerosis Research
Gene Backgrounds Storing Status
4930544G11Rik C57BL/6J Cryopreserved Sperms
Actb C57BL/6J Cryopreserved Sperms
Acvr1 C57BL/6J Cryopreserved Sperms
Acvr2a C57BL/6J Cryopreserved Sperms
Acvr2b C57BL/6J Cryopreserved Sperms
Akt1 C57BL/6N Cryopreserved Sperms, Live Mice
Akt2 C57BL/6J Cryopreserved Sperms
Akt3 C57BL/6J Cryopreserved Sperms
Arhgef2 C57BL/6J Cryopreserved Sperms
Ass1 C57BL/6J Cryopreserved Sperms
BC051665 C57BL/6J Cryopreserved Sperms
Bcl2 C57BL/6J Cryopreserved Sperms
Bmp4 C57BL/6J Cryopreserved Sperms
Bmpr1a C57BL/6J Cryopreserved Sperms
Bmpr1b C57BL/6J Cryopreserved Sperms
Bmpr2 C57BL/6J Cryopreserved Sperms
Calm1 C57BL/6J Cryopreserved Sperms
Calm2 C57BL/6J Cryopreserved Sperms
Calm3 C57BL/6J Cryopreserved Sperms
Calml3 C57BL/6J Cryopreserved Sperms
Calml4 C57BL/6J Cryopreserved Sperms
Cav1 C57BL/6N Cryopreserved Sperms, Live Mice
Cav2 C57BL/6N Cryopreserved Sperms, Live Mice
Cav3 C57BL/6N Cryopreserved Sperms, Live Mice
Ccl12 C57BL/6J Cryopreserved Sperms
Ccl2 C57BL/6N Cryopreserved Sperms, Live Mice
Cdh5 C57BL/6J Cryopreserved Sperms
Chuk C57BL/6J Cryopreserved Sperms
Ctnnb1 C57BL/6N Cryopreserved Sperms, Live Mice
Cts6 C57BL/6J Cryopreserved Sperms
Ctsl C57BL/6J Cryopreserved Sperms
Ctsll3 C57BL/6J Cryopreserved Sperms
Cyba C57BL/6J Cryopreserved Sperms
Dusp1 C57BL/6N Cryopreserved Sperms, Live Mice
Edn1 C57BL/6J Cryopreserved Sperms
Fos C57BL/6J Cryopreserved Sperms
Gpc1 C57BL/6J Cryopreserved Sperms
Gsta3 C57BL/6J Cryopreserved Sperms
Gsta4 C57BL/6J Cryopreserved Sperms
Gstm1 C57BL/6J Cryopreserved Sperms
Gstm2 C57BL/6J Cryopreserved Sperms
Gstm3 C57BL/6J Cryopreserved Sperms
Gstm4 C57BL/6J Cryopreserved Sperms
Gstm5 C57BL/6J Cryopreserved Sperms
Gstm6 C57BL/6J Cryopreserved Sperms
Gstm7 C57BL/6J Cryopreserved Sperms
Gsto1 C57BL/6J Cryopreserved Sperms
Gsto2 C57BL/6J Cryopreserved Sperms
Gstp1 C57BL/6J Cryopreserved Sperms
Gstp2 C57BL/6J Cryopreserved Sperms
Gstp3 C57BL/6J Cryopreserved Sperms
Gstt1 C57BL/6J Cryopreserved Sperms
Gstt2 C57BL/6J Cryopreserved Sperms
Gstt3 C57BL/6J Cryopreserved Sperms
Gstt4 C57BL/6J Cryopreserved Sperms
Hsp90b1 C57BL/6J Cryopreserved Sperms
Icam1 C57BL/6J Cryopreserved Sperms
Ifng C57BL/6N Cryopreserved Sperms, Live Mice
Ikbkb C57BL/6J Cryopreserved Sperms
Ikbkg C57BL/6J Cryopreserved Sperms
Il1a C57BL/6N Cryopreserved Sperms, Live Mice
Il1b C57BL/6N Cryopreserved Sperms, Live Mice
Il1r1 C57BL/6J Cryopreserved Sperms
Il1r2 C57BL/6N Cryopreserved Sperms, Live Mice
Itga2b C57BL/6J Cryopreserved Sperms
Itgav C57BL/6J Cryopreserved Sperms
Itgb3 C57BL/6J Cryopreserved Sperms
Jun C57BL/6J Cryopreserved Sperms
Kdr C57BL/6J Cryopreserved Sperms
Keap1 C57BL/6J Cryopreserved Sperms
Klf2 C57BL/6J Cryopreserved Sperms
Map2k4 C57BL/6J Cryopreserved Sperms
Map2k5 C57BL/6J Cryopreserved Sperms
Map2k6 C57BL/6J Cryopreserved Sperms
Map2k7 C57BL/6J Cryopreserved Sperms
Map3k5 C57BL/6N Cryopreserved Sperms, Live Mice
Map3k7 C57BL/6J Cryopreserved Sperms
Mapk10 C57BL/6J Cryopreserved Sperms
Mapk11 C57BL/6J Cryopreserved Sperms
Mapk12 C57BL/6J Cryopreserved Sperms
Mapk13 C57BL/6J Cryopreserved Sperms
Mapk14 C57BL/6J Cryopreserved Sperms
Mapk7 C57BL/6J Cryopreserved Sperms
Mapk8 C57BL/6J Cryopreserved Sperms
Mapk9 C57BL/6J Cryopreserved Sperms
Mef2a C57BL/6J Cryopreserved Sperms
Mef2c C57BL/6J Cryopreserved Sperms
Mgst1 C57BL/6J Cryopreserved Sperms
Mgst2 C57BL/6J Cryopreserved Sperms
Mgst3 C57BL/6J Cryopreserved Sperms
Mmp2 C57BL/6N Cryopreserved Sperms, Live Mice
Mmp9 C57BL/6N Cryopreserved Sperms, Live Mice
Ncf1 C57BL/6J Cryopreserved Sperms
Ncf2 C57BL/6J Cryopreserved Sperms
Nfe2l2 C57BL/6N Cryopreserved Sperms, Live Mice
Nfkb1 C57BL/6J Cryopreserved Sperms
Nos3 C57BL/6N Cryopreserved Sperms, Live Mice
Nox1 C57BL/6J Cryopreserved Sperms
Nppc C57BL/6J Cryopreserved Sperms
Nqo1 C57BL/6J Cryopreserved Sperms
Pdgfa C57BL/6J Cryopreserved Sperms
Pdgfb C57BL/6J Cryopreserved Sperms
Pecam1 C57BL/6N Cryopreserved Sperms, Live Mice
Pias4 C57BL/6J Cryopreserved Sperms
Pik3ca C57BL/6J Cryopreserved Sperms
Pik3cb C57BL/6J Cryopreserved Sperms
Pik3cd C57BL/6J Cryopreserved Sperms
Pik3r1 C57BL/6J Cryopreserved Sperms
Pik3r2 C57BL/6J Cryopreserved Sperms
Pik3r3 C57BL/6J Cryopreserved Sperms
Plat C57BL/6J Cryopreserved Sperms
Prkaa1 C57BL/6N Cryopreserved Sperms, Live Mice
Prkaa2 C57BL/6N Cryopreserved Sperms, Live Mice
Prkcz C57BL/6J Cryopreserved Sperms
Ptk2 C57BL/6J Cryopreserved Sperms
Rac1 C57BL/6J Cryopreserved Sperms
Rac2 C57BL/6J Cryopreserved Sperms
Rac3 C57BL/6J Cryopreserved Sperms
Rela C57BL/6J Cryopreserved Sperms
Rhoa C57BL/6J Cryopreserved Sperms
Sdc1 C57BL/6N Cryopreserved Sperms, Live Mice
Sdc2 C57BL/6J Cryopreserved Sperms
Sdc4 C57BL/6N Cryopreserved Sperms, Live Mice
Sele C57BL/6J Cryopreserved Sperms
Sqstm1 C57BL/6N Cryopreserved Sperms, Live Mice
Src C57BL/6J Cryopreserved Sperms
Sumo1 C57BL/6N Cryopreserved Sperms, Live Mice
Sumo2 C57BL/6J Cryopreserved Sperms
Thbd C57BL/6J Cryopreserved Sperms
Tnf C57BL/6N Cryopreserved Sperms, Live Mice
Tnfrsf1a C57BL/6N Cryopreserved Sperms, Live Mice
Trp53 C57BL/6J Cryopreserved Sperms, Live Mice
Trpv4 C57BL/6N Cryopreserved Sperms, Live Mice
Txn1 C57BL/6J Cryopreserved Sperms
Txn2 C57BL/6J Cryopreserved Sperms
Vegfa C57BL/6J Cryopreserved Sperms
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