녹아웃(KO) 마우스 | Cyagen Korea

Citations

What Our Customers Say

“Among several commercial services who have claimed to be specialized to generate mouse models with genetic modifications, I recognize that Cyagen is one of the best. We are looking forward to having more cooperation with them.”

Korea Brain Research Institute (KBRI)

more ›

Contact Us

영업일 기준 1-2일 내에 답변해 드리겠습니다.

*

The username is required

*

The user's email is required

Please enter a valid email address.

*

The user's phone is required

Please enter a valid phone address.

*

The content is required

*

비알코올성 지방간 유전자 변형 마우스 모델

Request a Quote or Information

 

간세포 지방의 생성 및 제거는 다양한 유전자에 의해 조절되며, 그의 돌연변이, 결실, 과발현 또는 변형은 지방의 대사에 영향을 미칠 수 있어 지방간을 형성한다. 따라서 동물의 유전자에 인위적으로 관여하면 NAFLD 동물 모델을 만들 수 있다.

 

1. PTEN Gene Knockout Mice

PTEN은 간세포 지방산의 β 산화와 트리글리세리드 합성에 관여하는 지질 포스파타아제로 세포자연사, 세포 증식 및 분화, 종양 형성 등의 신호통로에서 negative regulator 역할을 한다. Sato W 등은 간-특이성 PTEN 유전자 Knock-Out 마우스가 인간 NASH와 유사한 간 손상을 가질 수 있음을 발견했다. 이러한 마우스는 생후 10주 후에 연속적으로 지방 간염, 간 섬유화 및 간선종이 발생할 수 있으며 마지막에 66%의 마우스들이 간세포암종을 병발한다.

 

2. Apoe Gene Knockout Mice

죽상동맥경화증 연구에서 일반적으로 사용되는 Apoe Knock-Out 마우스는 고지방, 고콜레스테롤 식이를 먹일 때 지방변성, 염증 및 섬유화과 같은 NASH 표현형을 일으킬 수 있다.

검사항목: 체중, 음식 섭취량, 혈청생화학적검사(alanine aminotransferase, aspartate aminotransferase, serum total cholesterol, triglyceride content 등), 간조직 병리학적 형태 분석(간조직 H&E 염색, Oil red)

 

3. Other Genetically Modified Mouse Models Related to Non-Alcoholic Fatty Liver Disease(NAFLD) Research
Gene Backgrounds Storing Status
Adipoq C57BL/6N Cryopreserved Sperms, Live Mice
Adipor1 C57BL/6J Cryopreserved Sperms
Adipor2 C57BL/6J Cryopreserved Sperms
Akt1 C57BL/6N Cryopreserved Sperms, Live Mice
Akt2 C57BL/6J Cryopreserved Sperms
Akt3 C57BL/6J Cryopreserved Sperms
Atf4 C57BL/6J Cryopreserved Sperms
Bax C57BL/6J Cryopreserved Sperms
Bcl2l11 C57BL/6J Cryopreserved Sperms
Bid C57BL/6J Cryopreserved Sperms
Casp3 C57BL/6J Cryopreserved Sperms
Casp7 C57BL/6J Cryopreserved Sperms
Casp8 C57BL/6J Cryopreserved Sperms
Cdc42 C57BL/6J Cryopreserved Sperms
Cebpa C57BL/6J Cryopreserved Sperms
Cox4i1 C57BL/6J Cryopreserved Sperms
Cox4i2 C57BL/6J Cryopreserved Sperms
Cox5a C57BL/6J Cryopreserved Sperms
Cox5b C57BL/6J Cryopreserved Sperms
Cox6a1 C57BL/6J Cryopreserved Sperms
Cox6b1 C57BL/6J Cryopreserved Sperms
Cox6b2 C57BL/6J Cryopreserved Sperms, Live Mice
Cox6c C57BL/6N Cryopreserved Sperms, Live Mice
Cox7a1 C57BL/6J Cryopreserved Sperms
Cox7a2 C57BL/6J Cryopreserved Sperms
Cox7a2l C57BL/6N Cryopreserved Sperms, Live Mice
Cox7b C57BL/6J Cryopreserved Sperms
Cox7b2 C57BL/6J Cryopreserved Sperms
Cox7c C57BL/6J Cryopreserved Sperms
Cox8a C57BL/6J Cryopreserved Sperms
Cox8b C57BL/6J Cryopreserved Sperms
Cox8c C57BL/6J Cryopreserved Sperms
Cyc1 C57BL/6J Cryopreserved Sperms
Cycs C57BL/6J Cryopreserved Sperms
Cyct C57BL/6J Cryopreserved Sperms
Cyp2e1 C57BL/6J Cryopreserved Sperms
Eif2ak3 C57BL/6J Cryopreserved Sperms
Eif2s1 C57BL/6J Cryopreserved Sperms
Ern1 C57BL/6J Cryopreserved Sperms
Fas C57BL/6N Cryopreserved Sperms, Live Mice
Fasl C57BL/6J Cryopreserved Sperms
Fos C57BL/6J Cryopreserved Sperms
Gsk3a C57BL/6J Cryopreserved Sperms
Gsk3b C57BL/6J Cryopreserved Sperms
Ikbkb C57BL/6J Cryopreserved Sperms
Il1a C57BL/6N Cryopreserved Sperms, Live Mice
Il1b C57BL/6N Cryopreserved Sperms, Live Mice
Il6 C57BL/6N Cryopreserved Sperms, Live Mice
Il6ra C57BL/6N Cryopreserved Sperms, Live Mice
Ins1 C57BL/6J Cryopreserved Sperms
Insr C57BL/6J Cryopreserved Sperms
Irs1 C57BL/6N Cryopreserved Sperms, Live Mice
Itch C57BL/6J Cryopreserved Sperms
Jun C57BL/6J Cryopreserved Sperms
Lep C57BL/6J Cryopreserved Sperms
Lepr C57BL/6J Cryopreserved Sperms
Map3k11 C57BL/6J Cryopreserved Sperms
Map3k5 C57BL/6N Cryopreserved Sperms, Live Mice
Mapk10 C57BL/6J Cryopreserved Sperms
Mapk8 C57BL/6J Cryopreserved Sperms
Mapk9 C57BL/6J Cryopreserved Sperms
Mlx C57BL/6J Cryopreserved Sperms
Mlxip C57BL/6J Cryopreserved Sperms
Mlxipl C57BL/6N Cryopreserved Sperms, Live Mice
Ndufa10 C57BL/6J Cryopreserved Sperms
Ndufa11 C57BL/6J Cryopreserved Sperms
Ndufa12 C57BL/6J Cryopreserved Sperms
Ndufa13 C57BL/6J Cryopreserved Sperms
Ndufa4 C57BL/6J Cryopreserved Sperms
Ndufa4l2 C57BL/6J Cryopreserved Sperms
Ndufa6 C57BL/6J Cryopreserved Sperms
Ndufa7 C57BL/6J Cryopreserved Sperms
Ndufa8 C57BL/6J Cryopreserved Sperms
Ndufa9 C57BL/6J Cryopreserved Sperms
Ndufab1 C57BL/6J Cryopreserved Sperms
Ndufb10 C57BL/6J Cryopreserved Sperms
Ndufb11 C57BL/6J Cryopreserved Sperms
Ndufb2 C57BL/6J Cryopreserved Sperms
Ndufb3 C57BL/6J Cryopreserved Sperms
Ndufb4 C57BL/6J Cryopreserved Sperms
Ndufb5 C57BL/6J Cryopreserved Sperms
Ndufb6 C57BL/6J Cryopreserved Sperms
Ndufb8 C57BL/6J Cryopreserved Sperms
Ndufc1 C57BL/6J Cryopreserved Sperms
Ndufc2 C57BL/6J Cryopreserved Sperms
Ndufs1 C57BL/6J Cryopreserved Sperms
Ndufs2 C57BL/6J Cryopreserved Sperms
Ndufs3 C57BL/6J Cryopreserved Sperms
Ndufs4 C57BL/6J Cryopreserved Sperms
Ndufs5 C57BL/6J Cryopreserved Sperms
Ndufs6 C57BL/6J Cryopreserved Sperms
Ndufs7 C57BL/6N Cryopreserved Sperms, Live Mice
Ndufs8 C57BL/6J Cryopreserved Sperms
Ndufv1 C57BL/6J Cryopreserved Sperms
Ndufv2 C57BL/6J Cryopreserved Sperms
Ndufv3 C57BL/6J Cryopreserved Sperms
Nfkb1 C57BL/6J Cryopreserved Sperms
Nr1h3 C57BL/6N Cryopreserved Sperms, Live Mice
Pik3ca C57BL/6J Cryopreserved Sperms
Pik3cb C57BL/6J Cryopreserved Sperms
Pik3cd C57BL/6J Cryopreserved Sperms
Pik3r1 C57BL/6J Cryopreserved Sperms
Pik3r2 C57BL/6J Cryopreserved Sperms
Pik3r3 C57BL/6J Cryopreserved Sperms
Pklr C57BL/6J Cryopreserved Sperms
Ppara C57BL/6N Cryopreserved Sperms, Live Mice
Prkaa1 C57BL/6N Cryopreserved Sperms, Live Mice
Prkaa2 C57BL/6N Cryopreserved Sperms, Live Mice
Prkab1 C57BL/6J Cryopreserved Sperms
Prkab2 C57BL/6J Cryopreserved Sperms
Prkag1 C57BL/6J Cryopreserved Sperms
Prkag2 C57BL/6N Cryopreserved Sperms, Live Mice
Prkag3 C57BL/6J Cryopreserved Sperms
Rac1 C57BL/6J Cryopreserved Sperms
Rela C57BL/6J Cryopreserved Sperms
Rxra C57BL/6J Cryopreserved Sperms
Sdha C57BL/6J Cryopreserved Sperms
Sdhb C57BL/6J Cryopreserved Sperms
Sdhc C57BL/6J Cryopreserved Sperms
Sdhd C57BL/6J Cryopreserved Sperms
Socs3 C57BL/6J Cryopreserved Sperms
Srebf1 C57BL/6J Cryopreserved Sperms
Tgfb1 C57BL/6J Cryopreserved Sperms
Tnf C57BL/6N Cryopreserved Sperms, Live Mice
Tnfrsf1a C57BL/6N Cryopreserved Sperms, Live Mice
Traf2 C57BL/6J Cryopreserved Sperms
Uqcr10 C57BL/6J Cryopreserved Sperms
Uqcr11 C57BL/6J Cryopreserved Sperms
Uqcrb C57BL/6J Cryopreserved Sperms
Uqcrc1 C57BL/6J Cryopreserved Sperms
Uqcrc2 C57BL/6J Cryopreserved Sperms
Uqcrfs1 C57BL/6J Cryopreserved Sperms
Uqcrh C57BL/6J Cryopreserved Sperms
Uqcrq C57BL/6J Cryopreserved Sperms
Xbp1 C57BL/6J Cryopreserved Sperms
위에 제품이나 서비스에 관심이 있으시면 저희한테 연락 부탁드립니다.

Your First Name can not be empty

Your Last Name can not be empty

Institution/Affiliation can not be empty

Please enter a valid email address.

Your Email can not be empty

The content can not be empty

The option can not be empty