The State of Genetically Modified Mouse Models in 2019 – Advances in Human Disease Research | Community>Bulletin

Genetically engineered animals remain essential for gaining proper understanding of human disease mechanisms and play an important role in a variety of research areas.

For your reference, we now briefly summarize several recent publications from researchers using custom genetically modified models for a broad range of human disease studies, including neurological disorders, inflammatory disorders, cardiovascular disease, oncology, immunology, and kidney disease.

Models	Research Applications	Title	Journal
Knockin mice (TurboKnockout® based)	Neurology	Oxytocin-dependent reopening of a social reward learning critical period with MDMA	Nature, 2019
Knockin mice (ESC based)	Cardiovasology	Using Gjd3-CreEGFP mice to examine atrioventricular node morphology and composition	Scientific Reports, 2019.
Knockout Mice	Inflammatory disorders	VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages.	Science Advances, 2019
	Neuropathology	AQP4ex is crucial for the anchoring of AQP4 at the astrocyte end-feet and for neuromyelitis optica antibody binding	Acta Neuropathologica Communications, 2019.
	Cardiovascular disease	Inhibition of S-Adenosyl homocysteine Hydrolase Induces Endothelial Dysfunction via Epigenetic Regulation of p66shc-Mediated Oxidative Stress Pathway	Circulation, 2019.
	Oncology	Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer	Free Radical Biology and Medicine, 2019.
Conditional Knockout Mice	Osteoarthritis	Hematopoietic PBX-interacting protein mediates cartilage degeneration during the pathogenesis of osteoarthritis.	Nature Communications, 2019.
	Cardiovascular disease	Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.	Journal of Experimental Medicine, 2019.
	Immunology	Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses	Immunity, 2019.
Point Mutation Mice	Pancreatic disease	Heterozygous Spink1 c.194+2T>C mutant mice spontaneously develop chronic pancreatitis.	Gut, 2019.
Point Mutation Mice (Rosa26)	Infertility	A pannexin 1 channelopathy causes human oocyte death	Science Translational Medicine, 2019.
Rosa26 Conditional knockout Mice	Kidney disease	Tubular NOX4 expression decreases in chronic kidney disease but does not modify fibrosis evolution	Redox Biology, 2019.
Transgenic Mice	Cancer immunotherapy	Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy.	Immunity, 2019.
Transgenic Mice	Immunology	Uniquely human CHRFAM7A gene increases the hematopoietic stem cell reservoir in mice and amplifies their inflammatory response	PNAS (Proceedings of the National Academy of Sciences of the United States of America), 2019.
Conditional Transgenic Mice	Colorectal Cancer (CRC)	CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p	Journal of Experimental & Clinical Cancer Research, 2019.
Humanized Mice (Conditional knockin)	Oncology	An orally active galectin-3 antagonist inhibits lung adenocarcinoma growth and augments response to PD-L1 blockade	Cancer Research, 2019.

Visit our Citations page for a comprehensive, searchable listing of publications using custom animal models from Cyagen.

Did we miss you? Please contact us if you have published your studies using custom animal models provided by Cyagen that are not yet included in our citation resources.

If you need more information regarding our technologies and how Cyagen can help you further your research, please feel free to contact us with your gene target(s) and our custom model generation experts will be in touch with you.

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