For more than a century, rodents have played a pivotal role in biomedical research, and provided experimental systems for investigating mammalian biology...
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Animal models play a vital role in modern biomedical research. In particular, mouse and rats are profoundly important. However, mice and rats are imperfect...
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The gold standard for genetically engineering mouse models is ES-cell based homologous recombination. However, this approach is very time-consuming...
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