TurboKnockout and CRISPR: Technologies for Rapid Generation of Gene Targeted Mouse/Rat Models

While genetically engineered mouse/rat models (GEMM) have been used widely in biomedical research and drug development, the design and generation of these models can be complicated, time-consuming and costly. In this presentation, Dr. Yu will first introduce CRISPR/Cas9-mediated genome editing in GEMM generation, and discuss the pros and cons of CRISPR/Cas9 platform, he will then introduce TurboKnockout, the newest ES-cell based gene targeting technology, which allows the generation of GEMM models in as fast as 6 months, 4-6 months shorter than the standard ES cell gene targeting approach. Lastly, Dr. Yu will highlight germ-free platform used for biomedical research.

Speaker: Dr Steve Xiaofeng Yu, Vice President of Technology, Cyagen US Inc.

Date: 2019.10.24 

Time: 10:00-11:00 am.

Seminar Room, HKU, Medical Block

Host: Dr Ai-Min Xu, Chair Professor

          Director, State Key Laboratory of Pharmaceutical Biotechnology, HKU