Faster! More Reliable! TurboKnockout

● AlphaKnockout - Free strategy designing tool
Genetically modified mice generated by gene targeting technologies such as ES targeting or CRISPR/Cas9 have been widely used to study gene functions and human diseases. However, even for sophisticated life scientists, it takes many hours of hard research to come up with a good gene targeting strategy. Cyagen’s gene targeting AI (artificial intelligence) expert system - AlphaKnockout can help you overcome these limitations - its fast, intelligent, reliable, reproducible, and best of all, free.

● TurboKnockout^® - Fastest ES-cell based gene targeting approach
Cyagen offers a one-stop solution for animal model generation. In addition to free strategy designing with AlphaKnockout, TurboKnockout^®, Cyagen's proprietary and the fastest ES-cell based gene targeting platform in the world, also allows you to generate conditional knockout/knockin mouse models in as short as 6 months, 4-6 months shorter than the standard approaches.

Order now, you can enjoy free Cre mice and cryopreservation of strains up to three years.

Service	Turnaround	Deliverables
Conditional knockout/knockin mice	6-8 months	4 TurboKnockout^® mice

How to Order?

service-apac@cyagen.com

86 20-31601779

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——— Highlights of TurboKnockout^® ———

Item	TurboKnockout^®	Traditional ES Cell Targeting
Turnaround	6-8 months	10-14 months
F0 founders	100% ES cell derived	Chimeras partially
Self-deleting selection cassette	Yes	No
Potential off-site target effects	No	No
Ability to introduce large fragment	Yes	Yes
Germline guarantee	Yes	Yes

Faster Turnaround with
TurboKnockout^®:

● TurboKnockout^® ES cell targeting: 6~8 months

● Traditional ES cell targeting: 10~14 months

——— Cyagen’s Advantages ———

Over 12 years of experience
in custom animal model
generation

Working with over 1,000
bioscience institutions
throughout the world

Over 2,300 citations
in SCI journals

Over 26,000 animal models
delivered to date

Our facility can house up to
150,000 SPF animals

An essential receptor for adeno-associated virus infection.
Nature 530:108 (2016) IF= 40.137

The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons.
Nat Genet 48:427 (2016) IF= 31.616

Loss of G s α Impairs Liver Regeneration through a Defect in the Crosstalk between cAMP and Growth Factor Signaling.
Cancer Cell 31:697 (2017) IF= 27.407

The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination.
Nat Immunol 18:214 (2017) IF= 21.506

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