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Single-targeted Immune Checkpoint Mice

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The activation of lymphocytes is a process involving multiple signals. The immune system needs to maintain an optimal balance between autoimmune disease prevention and tumor elimination. This balance is regulated by a series of costimulatory and inhibitory receptors/ligands, and the ligand/receptor pathways involved in this balance are called immune checkpoints. Immune checkpoint inhibitors are antibody drugs developed for the corresponding immune checkpoints, which mainly reactivate the anti-tumor immune response by blocking co-suppressive T cell signaling.

 

The amino acid sequence homology between the immune checkpoint genes of ordinary mice and the corresponding human genes is generally about 60%. However, under normal circumstances, antibodies that recognize human immune checkpoint proteins cannot identify the corresponding proteins in mice - which may be solved with the humanization of mouse immune checkpoint genes.

 

 Humanized PD-1 Mouse Model

hPD-1 expression in mice has a normal physiological expression and regulation mode. The hPD-1 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint PD-1 in fully immunocompetent mice.

☞ Click here to learn more about PD-1 humanized mice.

 

 Humanized CTLA-4 Mouse Model

hCTLA-4 expression in mice has a normal physiological expression and regulation mode. The hCTLA-4 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint CTLA-4 in fully immunocompetent mice.

☞ Click here to learn more about hCTLA-4 humanized mice.

 

 Humanized GITR Mouse Model

hGITR expression in mice has a normal physiological expression and regulation mode. The hGITR mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint GITR in fully immunocompetent mice.

☞ Click here to learn more about hGITR humanized mice.

 

 Humanized VISTA Mouse Model

hVISTA expression in mice has a normal physiological expression and regulation mode. In VISTA humanized mice, the combination of αmPD-1+αhVISTA has the best anti-tumor effect.

☞ Click here to learn more about hVISTA humanized mice.

 

 Humanized OX40 Mouse Model

hOX40 expression in mice has a normal physiological expression and regulation mode. When hOX40 mice transplanted with MC38 tumors were treated with αhOX40 (an analog of BMS-986178), the proliferation of tumors was significantly inhibited.

☞ Click here to learn more about hOX40 humanized mice.

 

 Humanized LIGHT Mouse Model

hLIGHT expression in mice has a normal physiological expression and regulation mode. In LIGHT humanized mice, increasing LIGHT stimulation increased the activation of T-cells.  

☞ Click here to learn more about LIGHT humanized mice.

 

 Humanized CD28 Mouse Model

CD28 expression in mice has a normal physiological expression and regulation mode. α-human CD28 co-stimulation affects T-cell activation and proliferation.

☞ Click here to learn more about CD28 humanized mice.

 

 Humanized CD39 Mouse Model

CD39 expression in mice has a normal physiological expression and regulation mode. The human CD39 antibody specifically inhibits the nucleotidase activity of human CD39.

☞ Click here to learn more about CD39 humanized mice.

 

In 2020, Cyagen reached a strategic partnership with genOway. Founded in 1999, genOway is a leading international supplier of laboratory mice for preclinical scientific research. Cyagen is excited to introduce Single-targeted Humanized Immune Checkpoint (ICP) Mouse as one of the selected mice product introduced in the cooperation - Why do we recommend genOway's mouse model?

 

1.  Robust verification by both Industry leaders and literatures: Services and products from genOway have been cited many times in high-impact academic journals such as Cell, Nature, Science, and PNAS. As a partner of the the EU Research and Innovation programme (Horizon 2020), its immune checkpoint (ICP) and severe combined immunodeficient (SCID) model series have been jointly verified by the company and its partners worldwide, including leaders in the fields of immuno-oncology and immunotherapy, large pharmaceutical companies, biotechnology companies, research institutions, and more.

 

2.  Leading supplier of genetically engineered animal models in Europe and the United States: genOway has obtained patent licenses for all its technologies used to construct models, and is the only supplier that can guarantee you the opportunity to operate all the models on your own. Founded in 1999, genOway has 21 years of experience in animal model services, the company now has developed into a leader in the field of customized, genetically modified (GM) mouse, rat, and cell model creation, while serving international pharmaceuticals (Novartis, Pfizer, BMS, Janssen, and more.) and world-famous academic research centers (National Institutes of Health (NIH), Institut Pasteur, etc.) with their services.

 

3.  Comprehensive Intellectual Property (IP) Protection: Clear and independent IP rights are an essential facet of successful drug discovery projects. genOway provides various disease animal models with a wide range of patents and license agreements to ensure that the IP rights of the model are clear. This guarantees you freedom to operate (FTO) along with the provisions of the model.

 

4.  Specific Model Genetic Background: All models are provided on a specific genetic strain background, of accurate and traceable sources, and includes periodic genetic testing performed in colony maintenance to ensure the reproducibility of your research results.

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