리포터 유전자를 내인성 타겟 유전자의 3'UTR에 삽입하고 양자를 IRES로 연결한다. 이와 같은 제작 방식은 타겟 유전자와 리포터 유전자를 두개의 서로 다른 단백질로 해석할 수 있다.
✔ IL-4-IRES-eGFP (4get) Mice
The reliable monitoring and sorting of IL-4-secreting cells enables you to efficiently delineate the immune response polarization toward the Th2 pathway and is a powerful drug testing tool.
✔ Foxp3-IRES-mRFP (FIR) Mice
This reliable Foxp3 reporter mouse model allows you to efficiently monitor and sort Foxp3-expressing cells from different lymphocyte lineages and lymphoid organs. It is a powerful drug testing tool.
✔ hGITR/Foxp3 Mice
The hGITR/Foxp3 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint GITR, and efficiently monitor and sort Foxp3-expressing cells from different lymphocyte lineages and lymphoid organs.
In 2020, Cyagen reached a strategic partnership with genOway. Founded in 1999, genOway is a leading international supplier of laboratory mice for preclinical scientific research. Cyagen is excited to introduce Single-targeted Humanized Immune Checkpoint (ICP) Mouse as one of the selected mice product introduced in the cooperation - Why do we recommend genOway's mouse model?
1. Robust verification by both Industry leaders and literatures: Services and products from genOway have been cited many times in high-impact academic journals such as Cell, Nature, Science, and PNAS. As a partner of the the EU Research and Innovation programme (Horizon 2020), its immune checkpoint (ICP) and severe combined immunodeficient (SCID) model series have been jointly verified by the company and its partners worldwide, including leaders in the fields of immuno-oncology and immunotherapy, large pharmaceutical companies, biotechnology companies, research institutions, and more.
2. Leading supplier of genetically engineered animal models in Europe and the United States: genOway has obtained patent licenses for all its technologies used to construct models, and is the only supplier that can guarantee you the opportunity to operate all the models on your own. Founded in 1999, genOway has 21 years of experience in animal model services, the company now has developed into a leader in the field of customized, genetically modified (GM) mouse, rat, and cell model creation, while serving international pharmaceuticals (Novartis, Pfizer, BMS, Janssen, and more.) and world-famous academic research centers (National Institutes of Health (NIH), Institut Pasteur, etc.) with their services.
3. Comprehensive Intellectual Property (IP) Protection: Clear and independent IP rights are an essential facet of successful drug discovery projects. genOway provides various disease animal models with a wide range of patents and license agreements to ensure that the IP rights of the model are clear. This guarantees you freedom to operate (FTO) along with the provisions of the model.
4. Specific Model Genetic Background: All models are provided on a specific genetic strain background, of accurate and traceable sources, and includes periodic genetic testing performed in colony maintenance to ensure the reproducibility of your research results.